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In vivo requirements for GATA-1 functional domains during primitive and definitive erythropoiesis

GATA-1 is a transcription factor essential for erythroid/megakaryocytic cell differentiation. To investigate the contribution of individual domains of GATA-1 to its activity, transgenic mice expressing either an N-terminus, or an N- or C-terminal zinc finger deletion of GATA-1 (ΔNT, ΔNF or ΔCF, resp...

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Udgivet i:EMBO J
Principais autores: Shimizu, Ritsuko, Takahashi, Satoru, Ohneda, Kinuko, Engel, James Douglas, Yamamoto, Masayuki
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2001
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125635/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11566888/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.18.5250
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