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Multiple roles for the C-terminal domain of eIF5 in translation initiation complex assembly and GTPase activation

eIF5 stimulates the GTPase activity of eIF2 bound to Met-tRNA(i)(Met), and its C-terminal domain (eIF5-CTD) bridges interaction between eIF2 and eIF3/eIF1 in a multifactor complex containing Met-tRNA(i)(Met). The tif5-7A mutation in eIF5-CTD, which destabilizes the multifactor complex in vivo, reduc...

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Udgivet i:EMBO J
Principais autores: Asano, Katsura, Shalev, Anath, Phan, Lon, Nielsen, Klaus, Clayton, Jason, Valášek, Leoš, Donahue, Thomas F., Hinnebusch, Alan G.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2001
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125443/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11331597/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.9.2326
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