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Loss of the maintenance methyltransferase, xDnmt1, induces apoptosis in Xenopus embryos
DNA methylation is necessary for normal embryogenesis in animals. Here we show that loss of the maintenance methyltransferase, xDnmt1p, triggers an apoptotic response during Xenopus development, which accounts for the loss of specific cell populations in hypomethylated embryos. Hypomethylation-induc...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2001
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC125419/ https://ncbi.nlm.nih.gov/pubmed/11296229 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.8.1963 |
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