Endocytosis of HIV-1 activates plasmacytoid dendritic cells via Toll-like receptor– viral RNA interactions

HIV-1 directly activates human plasmacytoid DCs (pDCs) by upregulating the expression of costimulatory and MHC molecules and maturation markers, increasing T cell stimulatory activity, and inducing the production of type I interferons and TNF-α. A consequence of this activation is the bystander matu...

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Detalhes bibliográficos
Main Authors: Beignon, Anne-Sophie, McKenna, Kelli, Skoberne, Mojca, Manches, Olivier, DaSilva, Ida, Kavanagh, Daniel G., Larsson, Marie, Gorelick, Robert J., Lifson, Jeffrey D., Bhardwaj, Nina
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2005
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1253628/
https://ncbi.nlm.nih.gov/pubmed/16224540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI26032
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