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Late endosome motility depends on lipids via the small GTPase Rab7
We report that lipids contribute to regulate the bidirectional motility of late endocytic compartments. Late endocytic vesicles loaded with cholesterol lose their dynamic properties, and become essentially immobile, including in cells from Niemann–Pick C patients. These vesicles then retain cytoplas...
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| Главные авторы: | , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2002
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC125356/ https://ncbi.nlm.nih.gov/pubmed/11889035 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/21.6.1289 |
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