Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate

Duplexes of 21–23 nucleotide (nt) RNAs are the sequence-specific mediators of RNA interference (RNAi) and post-transcriptional gene silencing (PTGS). Synthetic, short interfering RNAs (siRNAs) were examined in Drosophila melanogaster embryo lysate for their requirements regarding length, structure,...

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Pubblicato in:	EMBO J
Autori principali:	Elbashir, Sayda M., Martinez, Javier, Patkaniowska, Agnieszka, Lendeckel, Winfried, Tuschl, Thomas
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 2001
Soggetti:	Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125328/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11726523/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.23.6877
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