Hyperactivation of the yeast DNA damage checkpoint by TEL1 and DDC2 overexpression

The evolutionarily conserved yeast Mec1 and Tel1 protein kinases, as well as the Mec1-interacting protein Ddc2, are involved in the DNA damage checkpoint response. We show that regulation of Tel1 and Ddc2–Mec1 activities is important to modulate both activation and termination of checkpoint-mediated...

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Publié dans:	EMBO J
Auteurs principaux:	Clerici, Michela, Paciotti, Vera, Baldo, Veronica, Romano, Michele, Lucchini, Giovanna, Longhese, Maria Pia
Format:	Artigo
Langue:	Inglês
Publié:	Nature Publishing Group 2001
Sujets:	Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125310/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11707419/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.22.6485
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