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Hyperactivation of the yeast DNA damage checkpoint by TEL1 and DDC2 overexpression
The evolutionarily conserved yeast Mec1 and Tel1 protein kinases, as well as the Mec1-interacting protein Ddc2, are involved in the DNA damage checkpoint response. We show that regulation of Tel1 and Ddc2–Mec1 activities is important to modulate both activation and termination of checkpoint-mediated...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2001
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC125310/ https://ncbi.nlm.nih.gov/pubmed/11707419 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.22.6485 |
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