Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint

Mad2 is a key component of the spindle checkpoint, a device that controls the fidelity of chromosome segregation in mitosis. The ability of Mad2 to form oligomers in vitro has been correlated with its ability to block the cell cycle upon injection into Xenopus embryos. Here we show that Mad2 forms i...

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Pubblicato in:	EMBO J
Autori principali:	Sironi, Lucia, Melixetian, Marina, Faretta, Mario, Prosperini, Elena, Helin, Kristian, Musacchio, Andrea
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 2001
Soggetti:	Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125308/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11707408/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.22.6371
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