Three-dimensional domain swapping in the folded and molten-globule states of cystatins, an amyloid-forming structural superfamily

Cystatins, an amyloid-forming structural superfamily, form highly stable, domain-swapped dimers at physiological protein concentrations. In chicken cystatin, the active monomer is a kinetic trap en route to dimerization, and any changes in solution conditions or mutations that destabilize the folded...

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Hauptverfasser: Staniforth, Rosemary A., Giannini, Silva, Higgins, Lee D., Conroy, Matthew J., Hounslow, Andrea M., Jerala, Roman, Craven, C.Jeremy, Waltho, Jonathan P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2001
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC125266/
https://ncbi.nlm.nih.gov/pubmed/11532941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.17.4774
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