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Contribution of Mutation at Amino Acid 45 of AcrR to acrB Expression and Ciprofloxacin Resistance in Clinical and Veterinary Escherichia coli Isolates

Fluoroquinolone-resistant Escherichia coli isolates which overexpressed acrB and had a substitution at amino acid 45 of AcrR were complemented with wild-type acrR. Complementation led to increased sensitivity to ciprofloxacin and to ethidium bromide, suggesting that mutation at amino acid 45 of AcrR...

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Detalhes bibliográficos
Main Authors: Webber, Mark A., Talukder, Ashraf, Piddock, Laura J. V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1251554/
https://ncbi.nlm.nih.gov/pubmed/16189130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.10.4390-4392.2005
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