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Effects of aging on central and peripheral mammalian clocks

Circadian organization changes with age, but we do not know the extent to which age-related changes are the result of alterations in the central pacemakers, the peripheral oscillators, or the coupling mechanisms that hold the system together. By using transgenic rats with a luciferase (luc) reporter...

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Main Authors: Yamazaki, Shin, Straume, Marty, Tei, Hajime, Sakaki, Yoshiyuki, Menaker, Michael, Block, Gene D.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2002
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC125050/
https://ncbi.nlm.nih.gov/pubmed/12149444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.152318499
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