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Effects of aging on central and peripheral mammalian clocks

Circadian organization changes with age, but we do not know the extent to which age-related changes are the result of alterations in the central pacemakers, the peripheral oscillators, or the coupling mechanisms that hold the system together. By using transgenic rats with a luciferase (luc) reporter...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Yamazaki, Shin, Straume, Marty, Tei, Hajime, Sakaki, Yoshiyuki, Menaker, Michael, Block, Gene D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2002
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Online-Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125050/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12149444/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.152318499
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