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Cellular transcriptional profiling in influenza A virus-infected lung epithelial cells: The role of the nonstructural NS1 protein in the evasion of the host innate defense and its potential contribution to pandemic influenza

The NS1 protein of influenza A virus contributes to viral pathogenesis, primarily by enabling the virus to disarm the host cell type IFN defense system. We examined the downstream effects of NS1 protein expression during influenza A virus infection on global cellular mRNA levels by measuring express...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Geiss, Gary K., Salvatore, Mirella, Tumpey, Terrence M., Carter, Victoria S., Wang, Xiuyan, Basler, Christopher F., Taubenberger, Jeffery K., Bumgarner, Roger E., Palese, Peter, Katze, Michael G., García-Sastre, Adolfo
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2002
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125029/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12149435/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.112338099
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