NotI subtraction and NotI-specific microarrays to detect copy number and methylation changes in whole genomes

Methylation, deletions, and amplifications of cancer genes constitute important mechanisms in carcinogenesis. For genome-wide analysis of these changes, we propose the use of NotI clone microarrays and genomic subtraction, because NotI recognition sites are closely associated with CpG islands and ge...

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Main Authors: Li, Jingfeng, Protopopov, Alexei, Wang, Fuli, Senchenko, Vera, Petushkov, Valentin, Vorontsova, Olga, Petrenko, Lev, Zabarovska, Veronika, Muravenko, Olga, Braga, Eleonora, Kisselev, Lev, Lerman, Michael I., Kashuba, Vladimir, Klein, George, Ernberg, Ingemar, Wahlestedt, Claes, Zabarovsky, Eugene R.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2002
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC125025/
https://ncbi.nlm.nih.gov/pubmed/12149436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.132271699
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