An anti-transferrin receptor-avidin fusion protein exhibits both strong proapoptotic activity and the ability to deliver various molecules into cancer cells

We have developed an antibody fusion protein (anti-rat TfR IgG3-Av) with the ability to deliver different molecules into cancer cells. It consists of avidin genetically fused to the C(H)3 region of a human IgG3 specific for the rat transferrin receptor. It forms strong, noncovalent interactions with...

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Bibliographic Details
Main Authors: Ng, Patrick P., Dela Cruz, Jay S., Sorour, David N., Stinebaugh, James M., Shin, Seung-Uon, Shin, Daniel S., Morrison, Sherie L., Penichet, Manuel L.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2002
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC125019/
https://ncbi.nlm.nih.gov/pubmed/12149472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.162362999
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