Lytic replication-associated protein (RAP) encoded by Kaposi sarcoma-associated herpesvirus causes p21(CIP-1)-mediated G(1) cell cycle arrest through CCAAT/enhancer-binding protein-α

Kaposi sarcoma-associated herpesvirus (KSHV) is an oncogenic DNA virus that causes Kaposi sarcoma and AIDS-related primary effusion lymphoma (PEL). Here we show that KSHV lytic cycle replication in PEL cells induces G(1) cell cycle arrest, presumably to facilitate the progression of viral DNA replic...

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Detalhes bibliográficos
Main Authors: Wu, Frederick Y., Tang, Qi-Qun, Chen, Honglin, ApRhys, Colette, Farrell, Christopher, Chen, Jianmeng, Fujimuro, Masahiro, Lane, M. Daniel, Hayward, Gary S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2002
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC125013/
https://ncbi.nlm.nih.gov/pubmed/12145325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.162352299
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