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Crystal structure of monomeric human β-2-microglobulin reveals clues to its amyloidogenic properties

Dissociation of human β-2-microglobulin (β(2)m) from the heavy chain of the class I HLA complex is a critical first step in the formation of amyloid fibrils from this protein. As a consequence of renal failure, the concentration of circulating monomeric β(2)m increases, ultimately leading to deposit...

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Detalhes bibliográficos
Main Authors: Trinh, Chi H., Smith, David P., Kalverda, Arnout P., Phillips, Simon E. V., Radford, Sheena E.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC125010/
https://ncbi.nlm.nih.gov/pubmed/12119416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.152337399
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