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Crystal structure of monomeric human β-2-microglobulin reveals clues to its amyloidogenic properties
Dissociation of human β-2-microglobulin (β(2)m) from the heavy chain of the class I HLA complex is a critical first step in the formation of amyloid fibrils from this protein. As a consequence of renal failure, the concentration of circulating monomeric β(2)m increases, ultimately leading to deposit...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The National Academy of Sciences
2002
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC125010/ https://ncbi.nlm.nih.gov/pubmed/12119416 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.152337399 |
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