Improvement in Survival and Cardiac Metabolism After Gene Transfer of Sarcoplasmic Reticulum Ca(2+)-ATPase in a Rat Model of Heart Failure

BACKGROUND: In heart failure, sarcoplasmic reticulum (SR) Ca(2+)-ATPase (SERCA2a) activity is decreased, resulting in abnormal calcium handling and contractile dysfunction. We have previously shown that increasing SERCA2a expression by gene transfer improves ventricular function in a rat model of he...

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Autori principali: del Monte, Federica, Williams, Eric, Lebeche, Djemal, Schmidt, Ulrich, Rosenzweig, Anthony, Gwathmey, Judith K., Lewandowski, E. Douglas, Hajjar, Roger J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2001
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1249503/
https://ncbi.nlm.nih.gov/pubmed/11560860
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