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Sarcoplasmic reticulum Ca(2+) ATPase as a therapeutic target for heart failure
BACKGROUND: The cardiac isoform of the sarco/endoplasmic reticulum Ca(2+)ATPase (SERCA2a) plays a major role in controlling excitation/contraction coupling. In both experimental and clinical heart failure (HF), SERCA2a expression is significantly reduced which leads to abnormal Ca(2+) handling and d...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3001226/ https://ncbi.nlm.nih.gov/pubmed/20078230 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1517/14712590903321462 |
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