Restoration of Contractile Function in Isolated Cardiomyocytes From Failing Human Hearts by Gene Transfer of SERCA2a

BACKGROUND: Failing human myocardium is characterized by abnormal relaxation, a deficient sarcoplasmic reticulum (SR) Ca(2+) uptake, and a negative frequency response, which have all been related to a deficiency in the SR Ca(2+) ATPase (SERCA2a) pump. METHODS AND RESULTS: To test the hypothesis that...

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Main Authors: del Monte, Federica, Harding, Sian E., Schmidt, Ulrich, Matsui, Takashi, Kang, Zhao Bin, William Dec, G., Gwathmey, Judith K., Rosenzweig, Anthony, Hajjar, Roger J.
格式: Artigo
語言:Inglês
出版: 1999
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1249502/
https://ncbi.nlm.nih.gov/pubmed/10587333
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