Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase

The heterodimeric Elongin BC complex has been shown to interact in vitro and in cells with a conserved BC-box motif found in an increasing number of proteins including RNA polymerase II elongation factor Elongin A, suppressor of cytokine signaling (SOCS)-box proteins, and the von Hippel–Lindau tumor...

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Bibliographic Details
Main Authors: Brower, Christopher S., Sato, Shigeo, Tomomori-Sato, Chieri, Kamura, Takumi, Pause, Arnim, Stearman, Robert, Klausner, Richard D., Malik, Sohail, Lane, William S., Sorokina, Irina, Roeder, Robert G., Conaway, Joan Weliky, Conaway, Ronald C.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2002
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC124918/
https://ncbi.nlm.nih.gov/pubmed/12149480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.162424199
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