A Spontaneous Low-Pathogenic Variant of Theiler’s Virus Contains an Amino Acid Substitution within the Predominant VP1(233–250) T-Cell Epitope

Theiler’s murine encephalomyelitis virus (TMEV) induces immune-mediated demyelination after intracerebral inoculation of the virus into susceptible mouse strains. We isolated from a TMEV BeAn 8386 viral stock, a low-pathogenic variant which requires greater than a 10,000-fold increase in viral inocu...

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Pubblicato in:	J Virol
Autori principali:	Kim, Byung S., Yauch, Robert L., Bahk, Young Yil, Kang, Jeong-Ah, Dal Canto, Mauro C., Hall, Catherine Kappel
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1998
Soggetti:	Viral Pathogenesis and Immunity
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC124573/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9444995/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.72.2.1020-1027.1998
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