Diketo acid inhibitor mechanism and HIV-1 integrase: Implications for metal binding in the active site of phosphotransferase enzymes

The process of integrating the reverse-transcribed HIV-1 DNA into the host chromosomal DNA is catalyzed by the virally encoded enzyme integrase (IN). Integration requires two metal-dependent reactions, 3′ end processing and strand transfer. Compounds that contain a diketo acid moiety have been shown...

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Publicado en:	Proc Natl Acad Sci U S A
Autores principales:	Grobler, Jay A., Stillmock, Kara, Hu, Binghua, Witmer, Marc, Felock, Peter, Espeseth, Amy S., Wolfe, Abigail, Egbertson, Melissa, Bourgeois, Michele, Melamed, Jeffrey, Wai, John S., Young, Steve, Vacca, Joseph, Hazuda, Daria J.
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	National Academy of Sciences 2002
Materias:	Biological Sciences
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC124459/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11997448/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.092056199
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