Human α-synuclein-harboring familial Parkinson's disease-linked Ala-53 → Thr mutation causes neurodegenerative disease with α-synuclein aggregation in transgenic mice

Mutations in α-synuclein (α-Syn) cause Parkinson's disease (PD) in a small number of pedigrees with familial PD. Moreover, α-Syn accumulates as a major component of Lewy bodies and Lewy neurites, intraneuronal inclusions that are neuropathological hallmarks of PD. To better understand the patho...

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Detalhes bibliográficos
Main Authors: Lee, Michael K., Stirling, Wanda, Xu, Yanqun, Xu, Xueying, Qui, Dike, Mandir, Allen S., Dawson, Ted M., Copeland, Neal G., Jenkins, Nancy A., Price, Don L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2002
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC124407/
https://ncbi.nlm.nih.gov/pubmed/12084935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.132197599
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