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Role of Lkb1, the causative gene of Peutz–Jegher's syndrome, in embryogenesis and polyposis

Peutz–Jeghers syndrome (PJS) is a dominantly inherited human disorder characterized by gastrointestinal hamartomatous polyposis and mucocutaneous melanin pigmentation. LKB1 (STK11) serine/threonine kinase is the product of the causative gene of PJS, which has been mapped to chromosome 19p13.3. Howev...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Jishage, Kou-ichi, Nezu, Jun-ichi, Kawase, Yosuke, Iwata, Takamitsu, Watanabe, Miho, Miyoshi, Akio, Ose, Asuka, Habu, Kiyoshi, Kake, Takei, Kamada, Nobuo, Ueda, Otoya, Kinoshita, Michiko, Jenne, Dieter E., Shimane, Miyuki, Suzuki, Hiroshi
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2002
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC124396/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12060709/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.122254599
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