Inhibition of mitochondrial respiration by endogenous nitric oxide: A critical step in Fas signaling

We have found that activation of human adult T cell leukemia (Jurkat) cells with anti-Fas Ab leads, in a concentration-dependent manner, to an early burst of production of nitric oxide (NO), which inhibits cell respiration. This results in mitochondrial hyperpolarization, dependent on the hydrolysis...

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Dettagli Bibliografici
Autori principali: Beltrán, Belén, Quintero, Marisol, García-Zaragozá, Eugenia, O'Connor, Enrique, Esplugues, Juan V., Moncada, Salvador
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2002
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC124394/
https://ncbi.nlm.nih.gov/pubmed/12077295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.092259799
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