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Blockade of vascular endothelial growth factor receptor-3 signaling inhibits fibroblast growth factor-2-induced lymphangiogenesis in mouse cornea

Vascular endothelial growth factor receptor-3 (VEGFR-3) is a major mediator of lymphangiogenesis. Recently, VEGFR-3 ligands, VEGF-C, and VEGF-D were reported to promote tumor lymphangiogenesis and lymphatic metastasis, and these processes were inhibited by blocking of the VEGFR-3-signaling pathway....

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Autors principals: Kubo, Hajime, Cao, Renhai, Bräkenhielm, Ebba, Mäkinen, Taija, Cao, Yihai, Alitalo, Kari
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2002
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC124390/
https://ncbi.nlm.nih.gov/pubmed/12070340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.062040199
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