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Polynucleotide phosphorylase is a global regulator of virulence and persistency in Salmonella enterica

For many pathogens, the ability to regulate their replication in host cells is a key element in establishing persistency. Here, we identified a single point mutation in the gene for polynucleotide phosphorylase (PNPase) as a factor affecting bacterial invasion and intracellular replication, and whic...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Clements, Mark O., Eriksson, Sofia, Thompson, Arthur, Lucchini, Sacha, Hinton, Jay C. D., Normark, Staffan, Rhen, Mikael
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2002
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC124376/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12072563/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.132047099
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