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Polynucleotide phosphorylase is a global regulator of virulence and persistency in Salmonella enterica

For many pathogens, the ability to regulate their replication in host cells is a key element in establishing persistency. Here, we identified a single point mutation in the gene for polynucleotide phosphorylase (PNPase) as a factor affecting bacterial invasion and intracellular replication, and whic...

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Autori principali: Clements, Mark O., Eriksson, Sofia, Thompson, Arthur, Lucchini, Sacha, Hinton, Jay C. D., Normark, Staffan, Rhen, Mikael
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2002
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC124376/
https://ncbi.nlm.nih.gov/pubmed/12072563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.132047099
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