Contribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic mice

Endogenous metals may contribute to the accumulation of amyloid plaques in Alzheimer's disease. To specifically examine the role of synaptic zinc in the plaque accumulation, Tg2576 (also called APP2576) transgenic mice (hAPP(+)) expressing cerebral amyloid plaque pathology were crossed with mic...

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Hlavní autoři: Lee, Joo-Yong, Cole, Toby B., Palmiter, Richard D., Suh, Sang Won, Koh, Jae-Young
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 2002
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC124328/
https://ncbi.nlm.nih.gov/pubmed/12032347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.092034699
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