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Zinc finger as distance determinant in the flexible linker of intron endonuclease I-TevI

I-TevI, the phage T4 td intron-encoded endonuclease, recognizes a lengthy DNA target and initiates intron mobility by introducing a double-strand break in the homing site. The enzyme uses both sequence and distance determinants to cleave the DNA 23–25 bp upstream of the intron insertion site. I-TevI...

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Tallennettuna:
Julkaisussa:Proc Natl Acad Sci U S A
Päätekijät: Dean, Amy B., Stanger, Matt J., Dansereau, John T., Van Roey, Patrick, Derbyshire, Victoria, Belfort, Marlene
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2002
Aiheet:
Biochemistry
Linkit:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC124309/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12077294/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.082253699
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