Omnipotent decoding potential resides in eukaryotic translation termination factor eRF1 of variant-code organisms and is modulated by the interactions of amino acid sequences within domain 1

In eukaryotes, a single translational release factor, eRF1, deciphers three stop codons, although its decoding mechanism remains puzzling. In the ciliate Tetrahymena thermophila, UAA and UAG codons are reassigned to Gln codons. A yeast eRF1-domain swap containing Tetrahymena domain 1 responded only...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Ito, Koichi, Frolova, Ludmila, Seit-Nebi, Alim, Karamyshev, Andrey, Kisselev, Lev, Nakamura, Yoshikazu
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 2002
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC124286/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12084909/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.142690099
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