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Degranulating mast cells in fibrotic regions of human tumors and evidence that mast cell heparin interferes with the growth of tumor cells through a mechanism involving fibroblasts

BACKGROUND: The purpose of this study was to test the hypothesis that mast cells that are present in fibrotic regions of cancer can suppress the growth of tumor cells through an indirect mechanism involving peri-tumoral fibroblasts. METHODS: We first immunostained a wide variety of human cancers for...

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Main Authors: Samoszuk, Michael, Kanakubo, Emi, Chan, John K
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2005
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1242221/
https://ncbi.nlm.nih.gov/pubmed/16176582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-5-121
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