Production of Sepiapterin in Escherichia coli by Coexpression of Cyanobacterial GTP Cyclohydrolase I and Human 6-Pyruvoyltetrahydropterin Synthase

Synechocystis sp. strain PCC 6803 GTP cyclohydrolase I and human 6-pyruvoyltetrahydropterin synthase were coexpressed in Escherichia coli. The E. coli transformant produced sepiapterin, which was identified by high-performance liquid chromatography and enzymatically converted to dihydrobiopterin by...

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Veröffentlicht in:	Appl Environ Microbiol
Hauptverfasser:	Woo, Hyun Joo, Kang, Jee Yun, Choi, Yong Kee, Park, Young Shik
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2002
Schlagworte:	Physiology and Biotechnology
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC123912/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12039779/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AEM.68.6.3138-3140.2002
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