Cloning and characterization of a cAMP-specific phosphodiesterase (TbPDE2B) from Trypanosoma brucei

Here we report the cloning, expression, and characterization of a cAMP-specific phosphodiesterase (PDE) from Trypanosoma brucei (TbPDE2B). Using a bioinformatic approach, two different expressed sequence tag clones were identified and used to isolate the complete sequence of two identical PDE genes...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Rascón, Ana, Soderling, Scott H., Schaefer, Jonathan B., Beavo, Joseph A.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2002
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC123713/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11930017/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.002031599
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