Cloning and characterization of a cAMP-specific phosphodiesterase (TbPDE2B) from Trypanosoma brucei

Here we report the cloning, expression, and characterization of a cAMP-specific phosphodiesterase (PDE) from Trypanosoma brucei (TbPDE2B). Using a bioinformatic approach, two different expressed sequence tag clones were identified and used to isolate the complete sequence of two identical PDE genes...

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Detalles Bibliográficos
Main Authors: Rascón, Ana, Soderling, Scott H., Schaefer, Jonathan B., Beavo, Joseph A.
Formato: Artigo
Idioma:Inglês
Publicado: The National Academy of Sciences 2002
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC123713/
https://ncbi.nlm.nih.gov/pubmed/11930017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.002031599
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