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Evolutionarily Conserved and Nonconserved Cellular Localizations and Functions of Human SIRT Proteins

Sir2 is a NAD(+)-dependent protein deacetylase that extends lifespan in yeast and worms. This study examines seven human proteins homologous to Sir2 (SIRT1 through SIRT7) for cellular localization, expression profiles, protein deacetylation activity, and effects on human cell lifespan. We found that...

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Main Authors: Michishita, Eriko, Park, Jean Y., Burneskis, Jenna M., Barrett, J. Carl, Horikawa, Izumi
格式: Artigo
語言:Inglês
出版: The American Society for Cell Biology 2005
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1237069/
https://ncbi.nlm.nih.gov/pubmed/16079181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E05-01-0033
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