Desensitization of μ-opioid receptor-evoked potassium currents: Initiation at the receptor, expression at the effector
Many G protein-coupled receptor-mediated responses desensitize within minutes. Sustained stimulation of μ-opioid receptors (MORs), which primarily signal through G(i/o) proteins, leads to activation and subsequent desensitization of G protein-coupled inwardly rectifying potassium (GIRK) currents. We...
Uloženo v:
| Vydáno v: | Proc Natl Acad Sci U S A |
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| Hlavní autoři: | , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2002
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC123706/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11917119/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.072075399 |
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