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Evolutionary conservation suggests a regulatory function of AUG triplets in 5′-UTRs of eukaryotic genes

By comparing sequences of human, mouse and rat orthologous genes, we show that in 5′-untranslated regions (5′-UTRs) of mammalian cDNAs but not in 3′-UTRs or coding sequences, AUG is conserved to a significantly greater extent than any of the other 63 nt triplets. This effect is likely to reflect, pr...

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Hlavní autoři: Churbanov, Alexander, Rogozin, Igor B., Babenko, Vladimir N., Ali, Hesham, Koonin, Eugene V.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2005
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1236974/
https://ncbi.nlm.nih.gov/pubmed/16186132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki847
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