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MYC overexpression imposes a nonimmunogenic phenotype on Epstein–Barr virus-infected B cells

Lymphoblastoid cell lines, generated by immortalization of normal B cells by Epstein–Barr virus (EBV) in vitro, have strong antigen-presenting capacity, are sensitive to EBV-specific cytotoxic T cells, and are highly allostimulatory in mixed lymphocyte culture. By contrast, EBV-positive Burkitt lymp...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Staege, Martin S., Lee, Steven P., Frisan, Teresa, Mautner, Josef, Scholz, Siegfried, Pajic, Alexander, Rickinson, Alan B., Masucci, Maria G., Polack, Axel, Bornkamm, Georg W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2002
Schlagworte:
Biological Sciences
Online-Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC123685/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11917131/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.072495599
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