Endoplasmic reticulum localization of the low density lipoprotein receptor mediates presecretory degradation of apolipoprotein B

Mutations in the low density lipoprotein (LDL) receptor (LDLR) cause hypercholesterolemia because of inefficient LDL clearance from the circulation. In addition, there is a paradoxical oversecretion of the metabolic precursor of LDL, very low density lipoprotein (VLDL). We recently demonstrated that...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Gillian-Daniel, Donald L., Bates, Paul W., Tebon, Angie, Attie, Alan D.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2002
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC123649/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11904390/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.072557199
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