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Endoplasmic reticulum localization of the low density lipoprotein receptor mediates presecretory degradation of apolipoprotein B

Mutations in the low density lipoprotein (LDL) receptor (LDLR) cause hypercholesterolemia because of inefficient LDL clearance from the circulation. In addition, there is a paradoxical oversecretion of the metabolic precursor of LDL, very low density lipoprotein (VLDL). We recently demonstrated that...

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Main Authors: Gillian-Daniel, Donald L., Bates, Paul W., Tebon, Angie, Attie, Alan D.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The National Academy of Sciences 2002
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC123649/
https://ncbi.nlm.nih.gov/pubmed/11904390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.072557199
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