Phosphate backbone neutralization increases duplex DNA flexibility: A model for protein binding

An important component of protein–DNA recognition is the charge neutralization of DNA backbone phosphates and subsequent protein-induced DNA bending. Replacement of phosphates by neutral methylphosphonates has previously been shown to be a model for protein-induced bending. In addition to bending, t...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Okonogi, Tamara M., Alley, Stephen C., Harwood, Eric A., Hopkins, Paul B., Robinson, Bruce H.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2002
Assuntos:	Physical Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC123618/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11929991/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.072067799
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