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Phosphate backbone neutralization increases duplex DNA flexibility: A model for protein binding
An important component of protein–DNA recognition is the charge neutralization of DNA backbone phosphates and subsequent protein-induced DNA bending. Replacement of phosphates by neutral methylphosphonates has previously been shown to be a model for protein-induced bending. In addition to bending, t...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The National Academy of Sciences
2002
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC123618/ https://ncbi.nlm.nih.gov/pubmed/11929991 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.072067799 |
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