The role of immunosuppression in the efficacy of cancer gene therapy using adenovirus transfer of the herpes simplex thymidine kinase gene.

OBJECTIVE: To determine whether the immune system limits or improves the therapeutic efficacy of an adenovirus vector expressing the herpes simplex thymidine kinase (HSVtk) gene in a subcutaneous tumor model. BACKGROUND DATA: Enhanced immune reactions against tumors may be therapeutically useful. Ho...

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Detalhes bibliográficos
Main Authors: Elshami, A A, Kucharczuk, J C, Sterman, D H, Smythe, W R, Hwang, H C, Amin, K M, Litzky, L A, Albelda, S M, Kaiser, L R
Formato: Artigo
Idioma:Inglês
Publicado em: 1995
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1234809/
https://ncbi.nlm.nih.gov/pubmed/7677460
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