Targeted Ablation of the Abcc6 Gene Results in Ectopic Mineralization of Connective Tissues

Pseudoxanthoma elasticum (PXE), characterized by connective tissue mineralization of the skin, eyes, and cardiovascular system, is caused by mutations in the ABCC6 gene. ABCC6 encodes multidrug resistance-associated protein 6 (MRP6), which is expressed primarily in the liver and kidneys. Mechanisms...

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Auteurs principaux: Klement, John F., Matsuzaki, Yasushi, Jiang, Qiu-Jie, Terlizzi, Joseph, Choi, Hae Young, Fujimoto, Norihiro, Li, Kehua, Pulkkinen, Leena, Birk, David E., Sundberg, John P., Uitto, Jouni
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2005
Sujets:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1234326/
https://ncbi.nlm.nih.gov/pubmed/16135817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.18.8299-8310.2005
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