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Human NDR Kinases Are Rapidly Activated by MOB Proteins through Recruitment to the Plasma Membrane and Phosphorylation

Human nuclear Dbf2-related kinases (NDRs) are up-regulated in certain cancer types, yet their precise function(s) and regulatory mechanism(s) still remain to be defined. Here, we show that active (phosphorylated on Thr444) and inactive human NDRs are both mainly cytoplasmic. Moreover, NDR kinases co...

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Détails bibliographiques
Auteurs principaux: Hergovich, Alexander, Bichsel, Samuel J., Hemmings, Brian A.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2005
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1234321/
https://ncbi.nlm.nih.gov/pubmed/16135814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.18.8259-8272.2005
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