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Human NDR Kinases Are Rapidly Activated by MOB Proteins through Recruitment to the Plasma Membrane and Phosphorylation

Human nuclear Dbf2-related kinases (NDRs) are up-regulated in certain cancer types, yet their precise function(s) and regulatory mechanism(s) still remain to be defined. Here, we show that active (phosphorylated on Thr444) and inactive human NDRs are both mainly cytoplasmic. Moreover, NDR kinases co...

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Detalhes bibliográficos
Main Authors: Hergovich, Alexander, Bichsel, Samuel J., Hemmings, Brian A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1234321/
https://ncbi.nlm.nih.gov/pubmed/16135814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.18.8259-8272.2005
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