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Human NDR Kinases Are Rapidly Activated by MOB Proteins through Recruitment to the Plasma Membrane and Phosphorylation

Human nuclear Dbf2-related kinases (NDRs) are up-regulated in certain cancer types, yet their precise function(s) and regulatory mechanism(s) still remain to be defined. Here, we show that active (phosphorylated on Thr444) and inactive human NDRs are both mainly cytoplasmic. Moreover, NDR kinases co...

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Bibliografske podrobnosti
Main Authors: Hergovich, Alexander, Bichsel, Samuel J., Hemmings, Brian A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2005
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1234321/
https://ncbi.nlm.nih.gov/pubmed/16135814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.18.8259-8272.2005
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