Design of Novel Conformational and Genotype-Specific Antigens for Improving Sensitivity of Immunoassays for Hepatitis C Virus-Specific Antibodies

The current commercially licensed enzyme-linked immunosorbent assays (ELISAs) for hepatitis C virus (HCV) mainly use recombinant proteins containing linear epitopes. There is evidence, however, that conformational epitopes of HCV are more immunoreactive. Thus, we have designed an HCV antibody assay...

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Detalhes bibliográficos
Main Authors: Lin, Sansan, Arcangel, Phillip, Medina-Selby, Angelica, Coit, Doris, Ng, Philip, Nguyen, Steve, McCoin, Colin, Gyenes, Alex, Hu, Celine, Tandeske, Laura, Phelps, Bruce, Chien, David
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2005
Assuntos:
Virology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1234008/
https://ncbi.nlm.nih.gov/pubmed/16081931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.43.8.3917-3924.2005
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