A nonsense mutation in the gene encoding 2′-5′-oligoadenylate synthetase/L1 isoform is associated with West Nile virus susceptibility in laboratory mice

A mouse model has been established to investigate the genetic determinism of host susceptibility to West Nile (WN) virus, a member of the genus flavivirus and family Flaviviridae. Whereas WN virus causes encephalitis and death in most laboratory inbred mouse strains after peripheral inoculation, mos...

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Detalhes bibliográficos
Main Authors: Mashimo, Tomoji, Lucas, Marianne, Simon-Chazottes, Dominique, Frenkiel, Marie-Pascale, Montagutelli, Xavier, Ceccaldi, Pierre-Emmanuel, Deubel, Vincent, Guénet, Jean-Louis, Desprès, Philippe
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2002
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC123253/
https://ncbi.nlm.nih.gov/pubmed/12186974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.172195399
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